Course Catalog Design of system elements, case studies of medical system examples, computer-aided design methods, design of subsystems, product reliability. Dynamic modeling and control of selected biological and physiological processes.

Title Author(s) Publisher Year Title Author(s) Publisher Year Books

Text Book(s) Mathematical and Computer Modeling of physiological systems. Vincent C.Rideout Prentice Hall 1996 Physiological Control Systems - Analysis, Simulation, and Estimation Michael C.K Khoo IEEE Press/John Wiley 2000 References · Mathematical Modelling of Dynamic biological systems Ludwik Finkelstein & Ewart R. Carson (1986) · Modelling Dynamic Biological Systems Bruce Hannon & Matthias Ruth (1997) · Introduction To Matlab For Engineers William J. Palm III (2005) · mathematical models in Biology Leah Edelstein-Keshet (1988) · A First Course in MATHEMATICAL MODELING Franck R. Giordano, William P. Fox, Steven B. Horton & Maurice D. Weir(2009) · Mathematical Modeling in The Life Sciences Paul Doucet & Peter B. Sloep (1992) · Modeling Differential Equation in Biology Clifford Henry Taubes (2008) · Modeling and Simulating in Medicine and the life sciences (2nd edition) Franck C.Hoppensteadt and charles S.Peskin Springer,New York,2002 · Introduction to Biomedical Engineering John ENderle, Elsevier, 1999, Second

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Journals Internet links

· Annals of Biomedical Engineering · Journal of Medical Engineering and Technology · Computer Programs and Methods in Medicine · Medical Engineering and Physics · IEEE EMBS Book Series · IEEE Transactions on Biomedical Engineering · IEEE Transactions on Information Technology in Biomedicine · Physiological Measurement · http://www.bmes.org/ · http://arjournals.annualreviews.org/loi/bioeng?cookieSet=1 · http://www.aami.org/publications/BIT/index.html · http://www.biophysj.org/ · http://emb-magazine.bme.uconn.edu/ · http://emb-magazine.bme.uconn.edu/ · http://www.iee.org/Publish/Journals/ProfJourn/MBEC/ · http://spie.org/app/Publications/index.cfm?fuseaction=journals&type=jbo · http://www.biomedical-engineering-online.com/start.asp

Prerequisites by topic Prerequisites by course Co-requisites by course Prerequisite for

Prerequisites Biomedical Transport Phenomena BME 452 NA Artificial Organs, Bioinformatics

Objectives To provide the students with a guide to mathematical modeling techniques (a,b,c,d,e,g,k) To provide the students with a tool for simulation physiological systems (a,b,c,d,e,g,k,l) Understand how to build, analyze and develop models for physiological systems(a,b,c,d,e,g,k,l) Understand the simulation and control of selected physiological processes and biological systems (a,b,c,d,e,g,k,l)

Objectives and Outcomes Outcomes · Learn how to describe systems using Laplace transform and differential equations · Solving the mathematical models using different numerical and analytical method. · Learn how to use Matlab/Simulink as simulation software. · Use Simulink to simulate physiological systems · Develop and build engineering models that describe pressure flow systems such as cardiovascular and respiratory function · Simulate cardiovascular systems and Mass-Transport compartment modeling · Analyze Pharmacokinetic System

Week 1

Topics Covered Topics Introduction to mathematical modeling

Chapters in Text Chapter 1 (Text 2) and notes

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2-3 4 5-6 7-8 9-10 11-12 13-14 15-16

using Matlab/Simulink/Berkeley Mathematical Modeling Static analysis of physiological systems Analysis of Linear Systems Pressure flow modeling. Cardiovascular modeling. Respiratory system modeling Mass Transport :Compartment Modeling Multiple Modeling Heart flow and Thermoregulation Modeling

Chapter 2 (Text 2) and notes Chapter 3 (Text 2) and notes Chapter 4 (Text 2) and notes Chapter 4 (Text 1) and notes Chapter 5 (Text 1) and notes Chapter 2-3 (Text 1) and notes Chapter 6 (Text 1) and notes Chapter 7 (Text 2) and notes

Attendance Homework Student Conduct

Policy Class attendance is required and applied according to the university regulations (student's guide page 43). Data support the idea that class attendance improves learning. It is very difficult as well as uninspiring for me to help a student who does not attend lectures. What is created in the classroom cannot be reenacted. Make-up tests will be done according to the university regulations. Please see student's guide pages 44-45. Working homework problems is an essential part of this course and they represent a key opportunity to learn the subjects discussed. All homework problems assigned during a given week are due at the beginning of class on the second meeting of the following week unless otherwise stated. Late homework will not be accepted. Failure to turn in this particular homework on time will result in a grade of 0 (zero) for the homework contribution to your final grade. Team work is encouraged; however, the work one hands in must represent his/her own effort. Homework solutions will be discussed in class. There will be no handouts of homework solutions. All University regulations apply to this course. In particular, the policies concerning academic dishonesty and withdrawal from a course apply.

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Teaching & Learning Methods - Active learning, where students should be active and involved in the learning process inside the classroom, will be emphasized in the delivery of this course. - Different active learning methods/approaches such as: Engaged Learning, Project-Based Learning, Cooperative Learning, Problem-based Learning, Structured Problem-solving, will be used. - The teaching method that will be used in this course will be composed of a series of mini lectures interrupted with frequent discussions and brainstorming exercises. PowerPoint presentations will be prepared for the course materials. - A typical lecture would start with a short review (~ 5 minutes) using both PowerPoint presentations and the blackboard. This review will also depend on discussions which will gauge the students' digestion of the previous material. Then, the students would have a lecture on new materials using PowerPoint presentations and blackboard. The lecture presentation will be paused every 15 20 minutes with brainstorming questions and discussions that will allow the students to reflect and think in more depth about what they learned in that presentation. Then, some example problems will be presented and discussed with the students to illustrate the appropriate problem solving skills that the students should learn. The lecture will be continued for another 15 20 minutes, followed by examples and/or a quiz covering the materials taught in the previous two weeks.

Assessment Tool Homework, Project and quizzes First Exam Second Exam final exam

Evaluation Expected Due Date One week after homework problems are assigned According to the University examination schedule According to the University examination schedule According to the University final examination schedule

10% 25 % 25 % 40 %

Weight

Contribution of Course to Meeting the Professional Component The course contributes to building the fundamental basic concepts in Biomedical Engineering and Modeling.

Engineering Science 3.0 Credit Engineering Design

ABET Category Content

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VC Rideout

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