Formalin-fixed Paraffin-embedded Tissues, F Al

Tags: Target groups, Cancer Research, Biomedicine, Springer News, Discount group, Research Discount, applications, reproducible results, implementation advice, cell culture methods, Cell Culture, Target, Cell Culture Techniques, Methods in Molecular Biology, step-by-step detail, Cancer Cytogenetics, drug interactions, drug design, Biomedicine Springer News, Drug Metabolism and Pharmacokinetics, National Institute of Standards an Technology, Gene Expression, ribosome, medical importance, M. W. Robinson, North America, research, M. Rodnina, Chinese Academy of Sciences, USA Drug Metabolism and Pharmacokinetics, St. Anne de Bellevue, Cathepsin Proteases, drug discovery and development, Washington State University, drug development, University of Marburg Drug Design Methodology, Hochschule Furtwangen University, Genentech, Inc., Computer Imaging, technology, Chemical Nomenclature, ADME Properties, University of Arkansas, Fayetteville, AR, spatial aspects, Cancer Research Center, Pathogenic Organisms, drug discovery stage, Department of Food Science, computational methods, Due March 2011, development, Department of Poultry Science, Discount group P Y. M. Kwon, Cysteine Proteases, scope ranges, neurological disorders, Medicinal Chemistry, inhibitors, T. Honjo, cancer cell culture, Pathology Fields, Cancer Cell, Anticancer Complementary and Alternative Medicine, M. D. Cooper, Vanderbilt University, H. Koprowski, Protein-Protein Interactions, University of California San Francisco, M. B. Oldstone, S. Olsnes, phosphodiesterase, Glasgow University, Kuwait University, Joint Research Centre, McGill University, PDE inhibitors, Max Planck Institute for Biophysical Chemistry, Ultimo, Sydney, Australia, J. P. Dalton, Trematode Cysteine Proteases, W. Wintermeyer, Australia, Johns Hopkins University, University of Technology Sydney, Cytogenetic Methods, Cancer, Cytogenetics Methods, herbal medicine, Cancer Cell Culture Methods, refined methods, Vanderbilt University Medical Center, Structure And Function
Content: springer.com/NEWSonline
Springer News 1/2011
Biomedicine 1
F. Al-Mulla, Kuwait University, Safat, Kuwait (Ed.) Formalin-Fixed ParaffinEmbedded Tissues Methods and Protocols
M. Aschner, Vanderbilt University Medical Center, Nashville, TN, USA; C. Suсol, Institut d'Investigacions Biomиdiques de Barcelona, Spain; A. Bal-Price, Joint Research Centre, Ispra, Italy (Eds.) Cell Culture Techniques
L. J. Campbell, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia (Ed.) Cancer Cytogenetics Methods and Protocols
Presenting an area of research that intersects with and integrates diverse disciplines, including genomics, epigenetics, proteomics, and cellular biology, among others, Formalin-Fixed ParaffinEmbedded Tissues: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Compiled in order to provide researchers with up-to-date methodological information pertaining to the utilization of genomic, transcriptomic, and proteomic data in diagnosis, prognosis, and tailored therapy, the ultimate aim of this volume is to decipher diseases at a molecular level. Divided into multiple convenient chapters, this detailed book covers various techniques to construct and utilize tissue arrays, it also provides detailed protocols in immunohistochemistry, immunofluorescence, fluorescent and chromogenic in situ hybridization, and ultimately introduces protocols for FFPET microdissection and nucleic acids extraction for their utilization in advanced techniques such as microarray CGH, DNA methylation and pyrosequencing. Features 7 Includes well-established and tested methods and protocols 7 Provides step-by-step detail essential for reproducible results 7 Contains well-organized themes and key implementation advice from the experts Fields of interest Molecular Medicine; Pathology Target groups Professional/practitioner Discount group P
Societal, ethical, and cost-related issues, not to mention the need for sound scientific methods, have led to new and refined methods for the evaluation of health risks associated with neurotoxic compounds, relevant and predictive of exposure, relatively inexpensive, and ideally amenable to high throughput analysis and a reduction in animal use. Cell Culture Techniques presents thorough traditional chapters, such as those on various cell culture methods that have evolved over the years, as well as innovative approaches to neurotoxicologic testing. Accordingly, this detailed volume describes how Stem cells, computational biology, and other novel powerful methods can now be applied to address the challenges of neurotoxic testing. Features 7 Facilitates the study of adverse changes in the developing and mature brain alike 7 Features classic as well as innovative new approaches to neurotoxicologic testing 7 Aids in the reduction of the necessity of animal testing From the contents Guidance on Good Cell Culture Practice (GCCP).Induced Pluripotent Stem Cells (iPSCs): An Emerging Model System for the Study of Human Neurotoxicology.- Neural Stem Cells.- Primary Cultures for Neurotoxicity Testing.- Preparation and Use of Serum-Free Aggregating Brain Cell Cultures for Routine Neurotoxicity Screening.Cell Culture to Investigate Neurotoxicity and Neurodegeneration Utilizing Caenorhabditis elegans.- Modeling the Blood-Brain Barrier.- In vitro Models of the Blood-Cerebrospinal Fluid Barrier and Their Use in Neurotoxicological Research.- Introducing Cloned Genes into Cultured Neurons Providing Novel In vitro Models for Neuropathology and Neurotoxicity Studies.
Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients. Cancer Cytogenetics: Methods and Protocols presents eminently practical key cytogenetic and FISH techniques for every stage of diagnostic service. Experts in the field describe detailed cytogenetic analysis methods, fluorescence in situ hybridization and array methods currently being applied to investigate and diagnose different varieties of cancer. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory protocols. Features 7 Includes cutting-edge methods and protocols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts From the contents Evolution of Cytogenetic Methods in the Study of Cancer.- Fluorescence In situ Hybridization Methods and Troubleshooting Applied to Fixed Cell Suspensions.- Chronic Myeloid Leukemia: Cytogenetic Methods and Applications for Diagnosis and Treatment.- Cytogenetic Analysis in Acute Myeloid Leukaemia.- Cytogenetics in Myelodysplastic Syndromes.- Cytogenetics of Myeloproliferative Disorders.- Acute Lymphoblastic Leukaemia.- Cytogenetics Methods in Chronic Lymphocytic Leukaemia (CLL).- Genetic Abnormalities in Non-Hodgkin's Lymphoma as Revealed by Conventional and Molecular Cytogenetics Methods of Analysis. Fields of interest Cancer Research; Pathology
Fields of interest Neurosciences; Neurochemistry
Target groups Professional/practitioner
Target groups Professional/practitioner
Discount group P
Discount group P
Due March 2011
Due March 2011
2011. 295 p. 57 illus., 1 in color. (Methods in Molecular Biology, Volume 724) Hardcover 7 $139.00 ISBN 978-1-61779-054-6
2011. 500 p. 84 illus. (Neuromethods, Volume 56) Hardcover 7 $159.00 ISBN 978-1-61779-076-8
Due March 2011 2nd ed. 2011. 250 p. 43 illus., 9 in color. (Methods in Molecular Biology, Volume 730) Hardcover 7 $119.00 ISBN 978-1-61779-073-7
2 Biomedicine
Springer News 1/2011
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W. C. Cho, Queen Elizabeth Hospital, Hong Kong, China (Ed.) Evidence-based Anticancer Herbal Medicine Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers.Recently there have been encouraging results from both laboratory experiments and clinical trials demonstrating the anticancer effects of herbal medicine. There is considerable interest among oncologists and cancer researchers to find anticancer agents in herbal medicine. Features 7 Specialised book on the up-to-date scientific evidence for anticancer herbal medicine 7 Currently there is considerable interest among oncologists to find anticancer agents in herbal medicine 7 Provides an overview of the anticancer herbal medicines and remedies Fields of interest Cancer Research; Biomedicine general; Medicine/ Public Health, general Target groups Research
I. A. Cree, Queen Alexandra Hospital, Portsmouth, UK (Ed.) Cancer Cell Culture Methods and Protocols With many recent advances, cancer cell culture research is more important than ever before. This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided for the evaluation of clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Features 7 Includes cutting-edge methods and protocols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts From the contents Cancer Biology.- Principles of Cancer Cell Culture.- Storage of Cell Lines.- Characterization and Authentication of Cancer Cell Lines: An Overview.- Online Verification of Human Cell Line Identity by STR DNA Typing.- Cytogenetic Analysis of Cancer Cell Lines.- Cell Culture Contamination.- Detecting Mycoplasma Contamination in Cell Cultures by Polymerase Chain Reaction.- Elimination of Mycoplasma from Infected Cell Lines Using Antibiotics.- Quality Assurance and Good Laboratory Practice.- Generation of Lung Cancer Cell Line Variants by Drug Selection or Cloning.- Isolation and Culture of Colon Cancer Cells and Cell Lines.- Isolation and Culture of Melanoma and Naevus Cells and Cell Lines.- Isolation and Culture of Squamous Cell Carcinomalines.- Isolation and Culture of Ovarian Cancer Cells and Cell Lines.
Current Topics in Microbiology and Immunology Series editors: R. W. Compans, M. D. Cooper, H. Koprowski, F. Melchers, M. B. Oldstone, S. Olsnes, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, K. Aktories Volume 348 L. T. Vassilev, D. Fry, Hoffmann-La Roche Inc., Nutley, NJ, USA (Eds.) Small-Molecule Inhibitors of Protein-Protein Interactions In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field. Features 7 In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions 7 The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies 7 There are various focal points, including methodologies and the molecules themselves
Fields of interest Cancer Research; Cell Culture
Field of interest Biomedicine general
Target groups Professional/practitioner
Target groups Research
Discount group P
Discount group P
Due March 2011
Due April 2011
2011. XII, 520 p. (Evidence-based Anticancer Complementary and Alternative Medicine) Hardcover 7 $209.00 ISBN 978-94-007-0525-8
2nd ed. 2011. 485 p. 72 illus. (Methods in Molecular Biology, Volume 731) Hardcover 7 $139.00 ISBN 978-1-61779-079-9
Due January 2011 2011. X, 180 p. 63 illus., 20 in color. Hardcover 7 $189.00 ISBN 978-3-642-17082-9
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Biomedicine 3
S. H. Francis, Vanderbilt University, USA; M. Conti, University of California San Francisco (UCSF), San Francisco, CA, USA; M. D. Houslay, Glasgow University, UK (Eds.) Phosphodiesterases as Drug Targets Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors. Features 7 Provides a summary of the major concepts related to the design and use of PDE inhibitors 7 Describes exciting ideas and developments that are currently emerging in this dynamic and important field 7 Written by leading authorities in the field From the contents Phosphodiesterase inhibitors: History of pharmacology; PDE inhibitors: factors that influence potency, selectivity and action; A fission yeastbased platform for phosphodiesterase inhibitor high throughput screening and analyses of phosphodiesterase activity; The pharmacokinetics of PDE inhibitors and the impact of this on their efficacy and the therapeutic window; Structural insight into the substrate specificity of phosphodiesterases; The GAF-tandem domain of phosphodiesterase 5 as a potential drug target. Fields of interest Pharmacology/Toxicology; Medicinal Chemistry; Protein Structure Target groups Research Discount group P
M. Hayat, Distinguished Professor and Research Professor, Department of Biological Sciences, Kean University, Union, NJ (Ed.) Tumors of the Central Nervous System, Volume 2 Gliomas: Glioblastoma (Part 2) Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained. Features 7 Targeted therapy determined by molecular genetics is emphasized 7 Several imaging techniques for diagnosis and treatment assessment are detailed 7 Present and future therapeutic drugs against malignant gliomas are describe 7 The anti-tumor action of cyclosporine A and functionally-related drugs is explained 7 Brain tumor angiogenesis and glioma grading are described. Fields of interest Cancer Research; Neuroradiology; Neurosurgery Target groups Professional/practitioner Discount group P
K. K. Jain, Jain PharmaBiotech, Basel, Switzerland The Handbook of Neuroprotection Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative toward the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study. Features 7 Describes the neuroprotective effects of established and newer drugs which have undergone clinical trials 7 Provides comprehensive coverage of the topic through the prism of multiple neurological disorders 7 Serves as a key reference volume for neurologists and pharmacologists Contents Introduction.- Neuroprotective Agents.- Neuroprotection in Cerebrovascular Disease.- Neuroprotection in Traumatic Brain Injury.- Neuroprotection in Spinal Cord Injury.- Neuroprotection in Neurodegenerative Disorders.- Neuroprotection in Parkinson's Disease.- Neuroprotection in Alzheimer's Disease.- Neuroprotection in Huntington's Disease.- Neuroprotection in Amyotrophic Lateral Sclerosis.- Neuroprotection in Miscellaneous Neurological Disorders.- Neuroprotection of the Optic Nerve and the Retina.- Neuroprotection during Anesthesia and Surgery.- Future Prospects of Neuroprotective Therapies. Fields of interest Neurosciences; Neurology Target groups Professional/practitioner
Discount group P
Due April 2011
2011. 450 p. (Handbook of Experimental Pharmacology, Volume 204) Hardcover 7 approx. $459.00 ISBN 978-3-642-17968-6 Prepublication price, valid until September 15, 2011 7 approx. $389.00
Due March 2011 2011. XX, 980 p. Hardcover 7 $279.00 ISBN 978-94-007-0617-0
Due March 2011 2011. 350 p. 9 illus. Hardcover 7 $209.00 ISBN 978-1-61779-048-5
4 Biomedicine
Springer News 1/2011
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S. C. Khojasteh, H. Wong, C. E. Hop, Genentech, Inc., San Francisco, CA, USA Drug Metabolism and Pharmacokinetics Quick Guide Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept. Features 7 Covers a number of aspects of drug assessment at drug discovery and development stagesIncludes topics in pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations 7 Covers key concepts, with useful tables on physiological parameters, chemical structure, nomenclature, and moieties leading to bioactivation Contents Pharmacokinetics.- Drug Metabolizing Enzymes.Oral Absorption.- Transporters.- MetabolismBased Drug Interactions.- Biotransformation and Bioactivation.- Prediction of Human Pharmacokinetics.- Advances in Bioanalysis as it Relates to ADME.- ADME Properties and Their Dependence on Physicochemical Properties.- In Silico ADME Tools.- Approved Drugs.- Chemical Nomenclature. Fields of interest Pharmacology/Toxicology; Pharmacy; Biochemistry, general
G. Klebe, University of Marburg Drug Design Methodology, Concepts, and Mode-of-Action Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting proteinprotein interfaces. Fields of interest Biomedicine general; Chemistry/Food Science, general; Computer Imaging, Vision, Pattern Recognition and Graphics Target groups Research Discount group P
Y. M. Kwon, Department of Poultry Science, University of Arkansas, Fayetteville, AR, USA; S. C. Ricke, Department of Food Science, University of Arkansas, Fayetteville, AR, USA (Eds.) High-Throughput Next Generation Sequencing Methods and Applications Due to their novel concepts and extraordinary high-throughput sequencing capacity, the "next generation sequencing" methods allow scientists to grasp system-wide landscapes of the complex molecular events taking place in various biological systems, including microorganisms and microbial communities. These methods are now being recognized as essential tools for a more comprehensive and deeper understanding of the mechanisms underlying many biological processes. In High-Throughput Next Generation Sequencing: Methods and Applications, experts in the field explore the most recent advances in the applications of next generation sequencing technologies with an emphasis on microorganisms and their communities; however, the methods described in this book will also offer general applications relevant to the study of any living organisms. Features 7 Provides techniques necessary to grasp systemwide landscapes of complex molecular events 7 Supplies practical chapters with easy to follow instructions 7 Features key tips and implementation advice from the experts Fields of interest Human Genetics; Microbial Genetics and Genomics; Gene Expression Target groups Professional/practitioner Discount group P
Target groups Research
Discount group P
Due September 2011
Original German Edition published by Spektrum Akademischer Verlag, 2009
Due April 2011 2011. VII, 163 p. 57 illus. Softcover 7 approx. $49.00 ISBN 978-1-4419-5628-6
2011. XXX, 720 p. 400 illus. in color. Hardcover 7 approx. $549.00 ISBN 978-3-642-17906-8 2011. XXX, 720 p. 400 illus. in color. eReference 7 approx. $549.00 ISBN 978-3-642-17907-5 2011. XXX, 720 p. 400 illus. in color. Print + eReference 7 approx. $689.00 ISBN 978-3-642-17908-2
Due April 2011 2011. 260 p. 40 illus., 5 in color. (Methods in Molecular Biology, Volume 733) Hardcover 7 $119.00 ISBN 978-1-61779-088-1
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Biomedicine 5
C. Lu, Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, USA; J. Browse, J. G. Wallis, Institute of Biological Chemistry, Washington State University, Pullman, WA, USA (Eds.) cDNA Libraries
M. M. Mueller, Hochschule Furtwangen University and Head of Research Group Tumor and Microenvironment German at the Cancer Research Center, Heidelberg, Germany; N. Fusenig, Professor Emeritus University of Heidelberg, former division head at the German Cancer Research Center, Heidelberg, Germany (Eds.)
A. Petronis, Centre for Addiction and Mental Health, Toronto, ON, Canada; J. Mill, King's College London, UK (Eds.) Brain, Behavior and Epigenetics
Methods and Applications The numerous vital applications of complementary DNA (cDNA) technology have changed dramatically as the technology has advanced over recent years. In cDNA Libraries: Methods and Protocols, expert researchers provide current techniques that reflect the latest advances in the construction and application of cDNA libraries. The first half of the volume covers improved approaches to some of the most basic elements of creating cDNA libraries, while the second half casts a much wider net and includes visionary applications of cDNA technology which were either unforeseen or technically impractical until recently. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Features 7 Captures the current state of this everdeveloping and powerful technology 7 Features practical methodologies, ready for the lab 7 Contains vital implementation advice from experts in the field Fields of interest Human Genetics; Gene Expression Target groups Professional/practitioner Discount group P
Tumor-Associated Fibroblasts and their Matrix Tumor Stroma During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on "Tumor-associated fibroblasts and their matrix" as part of the series on "Tumor-Microenvironment" is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy. Features 7 First comprehensive compilation of expert reviews on tumor stroma and its role in tumor biology important for basic and clinical cancer researchers 7 Highlighting promising new targets for cancer therapy 7 Novel textbook for teaching tumor biology to graduate students Fields of interest Cancer Research; Biomedicine general; Oncology
Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? Features 7 Art Petronis' and Jon Mill's research is dedicated to the understanding of the role of epigenetic risk factors in complex diseases 7 Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical developmental stage 7 Epigenetics, a cellular mechanism once considered to be stable after development, has now been found to be a dynamic process that occurs in fully differentiated, post-mitotic cells of central nervous system in response to environmental signals Fields of interest Human Genetics; Psychiatry Target groups Research Discount group P
Target groups Research
Discount group P
Due March 2011
Due March 2011
2011. 260 p. 47 illus., 2 in color. (Methods in Molecular Biology, Volume 729) Hardcover 7 $119.00 ISBN 978-1-61779-064-5
2011. XX, 580 p. (The Tumor Microenvironment, Volume 4) Hardcover 7 $239.00 ISBN 978-94-007-0658-3
Due May 2011 2011. X, 335 p. 21 illus., 10 in color. (Epigenetics and Human Health) Hardcover 7 approx. $209.00 ISBN 978-3-642-17425-4
6 Biomedicine
Springer News 1/2011
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M. Ritsner, Professor of Psychiatry and Head of Cognitive & Psychobiology Research Laboratory, the Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel (Ed.) Handbook of Schizophrenia Spectrum Disorders, Volume I Conceptual Issues and Neurobiological Advances From the contents Foreword. Schizophrenia Spectrum Disorders: Insights from views across 100 years.- 1. The schizophrenia construct after 100 years of challenges.- 2. Diagnosis and classification of the schizophrenia spectrum disorders.- 3. Toward Multidimensional Continuum Model of functional psychoses for research purposes.- 4. Irving Gottesman and the schizophrenia spectrum.5. Schizotypy: Reflections on the bridge to schizophrenia and obstacles on the road ahead to etiology and pathogenesis.- 6. Autism spectrum disorders and schizophrenia.- 7. One hundred years of insanity: genomic, psychological, and evolutionary models of autism in relation to schizophrenia.- 8. Quantifying the dynamics of central systemic degeneration in schizophrenia.9. Schizophrenia runs in some families, but where are the genes?- 10. Changes in gene expression in subjects with schizophrenia associated with disease progression.- 11. Amino acids in schizophrenia ­ glycine, serine and arginine.- 12. Developmental consequences of prenatal immune activation.13. Glutamatergic neurotransmission abnormalities and schizophrenia.- 14. mathematical models in schizophrenia.- 15. Methamphetamine psychosis: a model for biomarker discovery in schizophrenia.- 16. What does proteomics tell us about schizophrenia?- 17. The role of 3-hydroxy5-pregnan-20-one in mediating the development and/or expression of schizophrenia spectrum disorders: Findings in rodents models and clinical populations.- 18. Neural substrates of emotion dysfunctions in patients with schizophrenia spectrum disorders.- 19. Brain morphological abnormalities at the onset of schizophrenia and other psychotic disorders. A review of the evidence. Fields of interest Neurosciences; Neurobiology; Neurology Target groups Research Discount group P
M. Ritsner, Professor of Psychiatry and Head of Cognitive & Psychobiology Research Laboratory, the Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel (Ed.) Handbook of Schizophrenia Spectrum Disorders, Volume II Phenotypic and Endophenotypic Presentations A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and Research Methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Features 7 Classification of the schizophrenia spectrum disorders 7 Neurobiological challenges 7 Phenotypic and endophenotypic presentations 7 Therapeutic approaches 7 Outcomes Fields of interest Neurosciences; Neurobiology; Neurology Target groups Research Discount group P
M. Ritsner, Technion - Israel Institute of Technology, Haifa, Israel (Ed.) Handbook of Schizophrenia Spectrum Disorders, Volume III Therapeutic Approaches, Comorbidity, and Outcomes Contents Foreword. Schizophrenia Spectrum Disorders: Insights from views across 100 years.- 1. Recovery in schizophrenia: perspectives, evidence, and implications.- 2. The magic shotgun: does it fit the clinician and will it point at schizophrenia?3. Advancing neuroprotective-based treatments for schizophrenia.- 4. Prevention and early intervention in at risk states for developing psychosis.5. Early improvement and its predictive validity in first-episode schizophrenia patients.- 6. Antioxidants as a treatment and prevention of tardive dyskinesia.- 7. Electrophysiological imaging evaluation of schizophrenia and treatment response.8. Coping with schizophrenia: measuring coping styles, patterns and temporal types.- 9. Interventions targeting social and vocational dysfunction in individuals with a schizophrenia spectrum disorder.- 10. Revisiting cognitive remediation for schizophrenia: Facing the challenges of the future.11. Individual psychotherapy for schizophrenia: an overview of its history, recent developments and new directions.- 12. An overview of cognitive behavior therapy in schizophrenic spectrum disorders.- 13. Schizophrenia and medical illness: consequences of schizophrenia or its treatment?14. The interface of cannabis misuse and schizophrenia-spectrum disorders.- 15. Schizophrenia and comorbid substance abuse ­ pathophysiological and therapeutic approaches.- 16. Suicidality and outcome in schizophrenia patients.- 17. The relationship between religiousness/spirituality and schizophrenia: implications for treatment and community support.- 18. The ethical ramifications of biomarker use for mood disorders.- Afterword. The future of the schizophrenia construct and acquisition of new knowledge. Fields of interest Neurosciences; Neurobiology; Neurology Target groups Research Discount group P
Due April 2011 2011. 200 p. 76 illus., 52 in color. Hardcover 7 approx. $189.00 ISBN 978-94-007-0836-5
Due April 2011 2011. 21 illus., 11 in color. Hardcover 7 approx. $189.00 ISBN 978-94-007-0830-3
Due April 2011 2011. 200 p. 11 illus., 5 in color. Hardcover 7 approx. $189.00 ISBN 978-94-007-0833-4
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M. W. Robinson, University of Technology Sydney, Ultimo, Sydney, Australia; J. P. Dalton, McGill University, St. Anne de Bellevue, Quebec, Canada (Eds.) Cysteine Proteases of Pathogenic Organisms
M. Rodnina, W. Wintermeyer, Max Planck Institute for Biophysical Chemistry, Gцttingen, Germany; R. Green, Johns Hopkins University, Baltimore, MD, USA (Eds.) Ribosomes: Structure, Function and Dynamics
Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structurefunction relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research. Features 7 Written by leading researchers from Europe, Australia and North America 7 Review recent developments in bacterial cysteine proteases 7 Focuses on protozoan parasites of medical importance 7 Covers cysteine proteases from helminths of medical and veterinary importance From the contents Papa InLike Proteases Of Staphylococcus Aureus.- The LysineSpecific Gingipain Of Porphyromonas: Importance To Pathogenicity.- Falcipains And Other Cysteine Proteases Of Malaria Parasites.- Cathepsin Proteases In Toxoplasma Gondii.- Entamoeba Histolytica CathepsinLike Enzymes.- Cysteine Peptidases Of Kinetoplastid Parasites.- Cruzain: The Path From Target Validation To The Clinic.- The Phylogeny, Structure And Function Of Trematode Cysteine Proteases, With Particular Emphasis On The Fasciola Hepatica Cathepsin L Family.- Cathepsins B1 And B2 Of Trichobilharzia Spp., Bird Schistosomes Causing Cercarial Dermatitis. Fields of interest Biomedicine general; Molecular Medicine Target groups Research
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come. Features 7 First ribosome book since 2001 7 Nobel Prize Chemistry 2009 -The Ribosome 7 Includes chapters of all three Nobel Prize winners 7 Comprehensive in scope Fields of interest Gene Expression; Nucleic Acid Chemistry; Biophysics and Biological Physics Target groups Research Discount group P
Discount group P
J. Zhou, G. Xie, Chinese Academy of Sciences, Beijing, China; X. Yan, National Institute of Standards an Technology (NIST), Rockville, MD, USA Encyclopedia of Traditional Chinese Medicines ­ Molecular Structures, Pharmacological Activities, Natural Sources and Applications This set of six volumes provides a systematic and standardized description of 23,033 chemical components isolated from 6,926 medicinal plants, collected from 5,535 books/articles published in Chinese and International Journals. A chemical structure with stereo-chemistry bonds is provided for each chemical component, in addition to conventional information, such as Chinese and English names, physical and chemical properties. It includes a name list of medicinal plants from which the chemical component was isolated. Furthermore, abundant pharmacological data for nearly 8,000 chemical components are presented, including experimental method, experimental animal, cell type, quantitative data, as well as control compound data. The seven indexes allow for complete cross-indexing. Regardless whether one searches for the molecular formula of a compound, the pharmacological activity of a compound, or the English name of a plant, the information in the book can be retrieved in multiple ways. Features 7 For the first time, a collection of more than 20,000 chemical components of medicinal plants for studying TCM is provided 7 Has a systematic and integrated approach 7 With seven indexes the information in the book can be retrieved in multiple ways Fields of interest Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Biochemistry, general Target groups Research Discount group P
Due March 2011 2011. XX, 222 p. 37 illus., 6 in color. (Advances in Experimental Medicine and Biology, Volume 712) Hardcover 7 $189.00 ISBN 978-1-4419-8413-5
Due May 2011
Due February 2011
2011. Approx. 600 p. 250 illus., 150 in color. Hardcover 7 approx. $239.00 ISBN 978-3-7091-0214-5
2011. XXVI, 3934 p. (6-volume-set) 7 $1349.00 ISBN 978-3-642-17733-0

F Al

File: formalin-fixed-paraffin-embedded-tissues.pdf
Author: F Al
Published: Sat Jan 29 18:35:55 2011
Pages: 7
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HAI Goonetileke Collection, 212 pages, 1.61 Mb

San Mateo County, 1 pages, 0.41 Mb
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